Phospho-Leptin Receptor (Tyr1141)抗体;Phospho-Leptin Receptor (Tyr1141) Antibody—艾普蒂 新品

+ +

•  

   

     Western blot analysis of Phospho-Leptin Receptor (Tyr1141) in K562 lysates using Phospho-Leptin Receptor (Tyr1141) antibody.    

  
  

The Phospho-Leptin Receptor (Tyr1141) antibody is a crucial tool for studying leptin signaling, a key pathway regulating energy homeostasis and metabolism. The leptin receptor (LEPR), a class I cytokine receptor, is activated upon leptin binding, triggering downstream signaling cascades via JAK-STAT, MAPK, and PI3K pathways. Tyr1141 phosphorylation in the intracellular domain of LEPR is a critical event following receptor activation, serving as a docking site for adaptor proteins like STAT3. This post-translational modification is essential for mediating leptin’s effects on appetite suppression, energy expenditure, and neuroendocrine function.

The Phospho-Leptin Receptor (Tyr1141) antibody specifically detects LEPR phosphorylated at this residue, enabling researchers to assess leptin receptor activation status in tissues such as the hypothalamus, adipose tissue, or liver. It is widely used in techniques like Western blotting, immunohistochemistry, and ELISA to investigate leptin resistance in metabolic disorders (e.g., obesity, diabetes) or leptin-related signaling dysregulation in cancer. Validation typically involves using leptin-stimulated samples or phosphatase-treated controls to confirm phosphorylation-dependent specificity. Understanding Tyr1141 phosphorylation dynamics provides insights into pathological mechanisms underlying metabolic syndromes and potential therapeutic targets.