Phospho-ITK (Tyr512)抗体;Phospho-ITK (Tyr512) Antibody—艾普蒂 新品

The Phospho-ITK (Tyr512) antibody is designed to detect the phosphorylated form of Interleukin-2-Inducible T-cell Kinase (ITK) at tyrosine residue 512. ITK, a member of the Tec family of non-receptor tyrosine kinases, plays a critical role in T-cell receptor (TCR) signaling and immune response regulation. Upon TCR activation, ITK is recruited to the membrane and undergoes phosphorylation at specific tyrosine residues, including Tyr512. which is associated with its enzymatic activation and downstream signaling. This phosphorylation event facilitates interactions with adaptor proteins (e.g., SLP-76) and promotes downstream pathways involving calcium flux, cytoskeletal reorganization, and cytokine production. The Phospho-ITK (Tyr512) antibody is widely used in immunological research to study T-cell activation, differentiation, and dysfunction in contexts such as autoimmune diseases, infections, and cancer. It enables detection of ITK activation status via techniques like Western blotting, flow cytometry, or immunofluorescence, providing insights into TCR signaling dynamics. Researchers also utilize this antibody to explore therapeutic targets for modulating aberrant T-cell responses. Specificity and validation data (e.g., knockout controls) are essential to confirm its reliability in experimental models.