Phospho-FGFR4 (Tyr642)抗体;Phospho-FGFR4 (Tyr642) Antibody—艾普蒂 新品

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     Western blot analysis of Phospho-FGFR4 (Tyr642) in Jurkat lysates using Phospho-FGFR4 (Tyr642) antibody.    

  
  

The Phospho-FGFR4 (Tyr642) antibody is a specialized tool used to detect the activated form of Fibroblast Growth Factor Receptor 4 (FGFR4) when phosphorylated at tyrosine residue 642. FGFR4. a member of the receptor tyrosine kinase (RTK) family, plays critical roles in regulating cell proliferation, differentiation, migration, and survival by binding FGF ligands and activating downstream signaling pathways, including MAPK/ERK, PI3K/AKT, and STAT. Phosphorylation at Tyr642 is a key event in FGFR4 activation, typically induced by ligand binding, dimerization, and autophosphorylation. This modification triggers conformational changes that facilitate the recruitment of adaptor proteins and signaling molecules.

The Phospho-FGFR4 (Tyr642) antibody is widely utilized in research to study FGFR4 signaling dynamics in physiological processes (e.g., tissue repair, metabolism) and pathological conditions, particularly cancers such as hepatocellular carcinoma, breast cancer, and rhabdomyosarcoma, where aberrant FGFR4 activation is linked to tumor progression and drug resistance. It is commonly employed in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess receptor activation status in cell lines, tissues, or preclinical models. Researchers also use this antibody to evaluate the efficacy of FGFR4-targeted therapies or investigate mechanisms underlying FGFR4-related diseases. Specificity validation via knockout/knockdown controls or peptide competition is recommended to ensure accurate detection.