Phospho-KCNQ2/3/4/5 (Thr217/Thr246/Thr223/Thr251)抗体;Phospho-KCNQ2/3/4/5 (Thr217/Thr246/Thr223/Thr251) Antibody—艾普蒂 新品

The Phospho-KCNQ2/3/4/5 (Thr217/Thr246/T223/T251) antibody is designed to detect phosphorylation at specific threonine residues within the KCNQ family of voltage-gated potassium channels (Kv7.2-7.5). These channels regulate neuronal excitability, cardiac repolarization, and epithelial electrolyte transport. Phosphorylation at these conserved sites (Thr217 in KCNQ2. Thr246 in KCNQ3. Thr223 in KCNQ4. Thr251 in KCNQ5) modulates channel activity by influencing gating properties, membrane trafficking, or interactions with regulatory proteins. For example, phosphorylation of KCNQ2/3 heteromers, critical for the neuronal M-current, may be regulated by kinases like PKC or PKA, impacting excitability in epilepsy or neuropathic pain models. The antibody is commonly used in Western blotting, immunohistochemistry, or immunofluorescence to study channel regulation in physiological or pathological contexts, such as arrhythmias, epilepsy, or channelopathy-related disorders. Its specificity for phosphorylated forms allows researchers to explore dynamic post-translational modifications that fine-tune channel function in response to signaling pathways. Validation typically includes knockout controls or phosphatase-treated samples to confirm target selectivity.