Phospho-EGFR (Tyr1092)抗体;Phospho-EGFR (Tyr1092) Antibody—艾普蒂

The phospho-EGFR (Tyr1092) antibody is a specialized tool used to detect epidermal growth factor receptor (EGFR) when phosphorylated at tyrosine residue 1092. EGFR, a transmembrane receptor tyrosine kinase, plays a critical role in regulating cell proliferation, survival, and differentiation. Upon ligand binding (e.g., EGF, TGF-α), EGFR undergoes dimerization and autophosphorylation at specific tyrosine residues within its intracellular kinase domain, including Tyr1092. This phosphorylation event creates docking sites for downstream signaling adaptors (e.g., GRB2. STAT) that activate pathways such as MAPK/ERK, PI3K/AKT, and JAK/STAT, driving cellular responses. Dysregulated EGFR signaling, often linked to hyperphosphorylation due to mutations or overexpression, is implicated in cancers, including lung, breast, and colorectal malignancies. The phospho-EGFR (Tyr1092) antibody specifically recognizes the activated (phosphorylated) form of EGFR at this site, enabling researchers to study receptor activation status in experimental models or clinical samples. It is widely used in techniques like Western blotting, immunohistochemistry, and flow cytometry to assess EGFR signaling activity in cancer biology, drug development (e.g., tyrosine kinase inhibitors), and biomarker studies. Validation of antibody specificity is crucial, as off-target binding may lead to misinterpretation of EGFR activation dynamics.