Phospho-Neurofilament Medium (Ser614/Ser619)抗体;Phospho-Neurofilament Medium (Ser614/Ser619) Antibody—艾普蒂 新品

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     Western blot analysis of Phospho-Neurofilament Medium (Ser614/619) in K562, Ramos, Daudi lysates using Phospho-Neurofilament Medium (Ser614/Ser619) antibody.    

  
  

Phospho-Neurofilament Medium (Ser614/Ser619) antibody specifically detects the phosphorylated form of the neurofilament medium (NF-M) chain at serine residues 614 and 619. Neurofilaments, composed of light (NFL), medium (NF-M), and heavy (NF-H) chains, are critical structural components of neuronal axons, maintaining cytoskeletal integrity and regulating axonal diameter. Phosphorylation of NF-M modulates neurofilament assembly, stability, and interactions with other cytoskeletal proteins, influencing axonal transport and mechanical strength.

The phosphorylation at Ser614/Ser619 is associated with neurofilament maturation and is dynamically regulated during neuronal development, injury, and degeneration. Aberrant phosphorylation, particularly at these sites, has been implicated in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Alzheimer’s disease, and Charcot-Marie-Tooth neuropathy. These modifications may contribute to pathological aggregation of neurofilaments, impairing axonal function and promoting neurodegeneration.

This antibody is widely used in neuroscience research to study neurofilament phosphorylation dynamics, neuronal health, and disease mechanisms. Applications include immunohistochemistry, Western blotting, and immunofluorescence in brain or spinal cord tissues. Its specificity helps distinguish pathological phosphorylation states from normal physiological modifications, offering insights into disease biomarkers and therapeutic targets. Researchers also utilize it to evaluate the effects of genetic or pharmacological interventions on neurofilament biology in experimental models.