Phospho-c-Jun (Thr93)抗体;Phospho-c-Jun (Thr93) Antibody—艾普蒂 新品

+ +

•  

   

     Western blot analysis of Phospho-c-Jun (Thr93) in 3T3, 293, PC-12 lysates using Phospho-c-Jun (Thr93) antibody.    

  
  

Phospho-c-Jun (Thr93) antibody is a specialized tool used to detect c-Jun protein phosphorylated at the threonine 93 residue. c-Jun, a key component of the AP-1 transcription factor complex, regulates cellular processes like proliferation, differentiation, and apoptosis. Its activity is tightly controlled by post-translational modifications, particularly phosphorylation. The Thr93 site, located within the transactivation domain, is phosphorylated by stress-activated kinases such as JNK (c-Jun N-terminal kinase) in response to extracellular stimuli, including cytokines, UV radiation, or growth factors. This modification enhances c-Jun’s transcriptional activity, promoting target gene expression involved in stress responses, inflammation, and oncogenesis.

The Phospho-c-Jun (Thr93) antibody enables researchers to study c-Jun activation dynamics in various contexts, such as cancer progression, immune regulation, or cellular stress pathways. It is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess phosphorylation status in cell lysates or tissue samples. Validated for specificity, this antibody helps elucidate mechanisms underlying diseases linked to AP-1 dysregulation, including inflammatory disorders and malignancies. By detecting Thr93 phosphorylation, it serves as a biomarker for JNK pathway activation, offering insights into signal transduction networks and therapeutic targeting strategies.