Phospho-LRRK2 (Ser395)抗体;Phospho-LRRK2 (Ser395) Antibody—艾普蒂 新品

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     Western blot analysis of Filamin A Phosphorylation in WTLRRK2 lysates treated LRRK2 using Phospho-LRRK2 (Ser395) antibody.    

  
  

Phospho-LRRK2 (Ser395) antibody is a specialized tool used to detect the phosphorylation of leucine-rich repeat kinase 2 (LRRK2) at serine residue 395. LRRK2. a large multidomain protein kinase, is implicated in regulating vesicular trafficking, autophagy, and inflammatory responses. Dysregulation of LRRK2. particularly through mutations like G2019S, is linked to familial and sporadic Parkinson’s disease (PD). Phosphorylation at Ser395. located in the non-catalytic COR domain, is a key post-translational modification influencing LRRK2’s kinase activity, interaction with binding partners, and subcellular localization. This site is phosphorylated by upstream kinases (e.g., PKA) or through autophosphorylation, modulating LRRK2’s role in signaling pathways.

The Phospho-LRRK2 (Ser395) antibody enables researchers to study LRRK2 activation states and regulatory mechanisms in disease models. It is widely used in Western blotting, immunofluorescence, and immunoprecipitation to assess phosphorylation levels in cell lines, brain tissues, or biofluids. Its specificity helps evaluate the efficacy of LRRK2 inhibitors in preclinical studies, as dephosphorylation at Ser395 often correlates with reduced kinase activity.

Research using this antibody has advanced understanding of LRRK2’s pathobiology, including its interaction with Rab GTPases and contribution to neuroinflammation or neuronal death in PD. Validated across species and sample types, it remains critical for exploring therapeutic strategies targeting LRRK2 hyperactivation.