Phospho-GATA3 (Ser308)抗体;Phospho-GATA3 (Ser308) Antibody—艾普蒂 新品

The Phospho-GATA3 (Ser308) antibody is designed to detect GATA3 protein when phosphorylated at serine residue 308. a post-translational modification critical for regulating its transcriptional activity. GATA3. a member of the GATA family of zinc-finger transcription factors, plays essential roles in immune cell development, particularly in T-cell differentiation and T-helper 2 (Th2) cell function. It also contributes to epithelial cell maintenance and is implicated in cancers, including breast cancer. Phosphorylation at Ser308 modulates GATA3’s stability, nuclear localization, and interaction with co-regulators, thereby influencing target gene expression. Studies suggest this modification may be mediated by kinases such as AKT or p38 MAPK under specific signaling conditions. The antibody is widely used in research to investigate Th2-mediated immune responses (e.g., allergies, asthma), cancer progression, and mechanisms of gene regulation. Detection of phosphorylated GATA3 helps clarify its activation state in cellular pathways and disease models. Validated applications include Western blotting, immunofluorescence, and immunohistochemistry, often in conjunction with total GATA3 antibodies to assess phosphorylation dynamics. Its utility extends to both basic research and translational studies exploring therapeutic targets in oncology and immune disorders.