Phospho-ErbB 4 (Tyr1162)抗体;Phospho-ErbB 4 (Tyr1162) Antibody—艾普蒂 新品

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     Western blot analysis of Phospho-ErbB 4 (Tyr1162) in Hela, A549 lysates using Phospho-ErbB 4 (Tyr1162) antibody.    

  
  

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     Immunohistochemistry analysis of paraffin-embedded Human breast cancer using ErbB 4 (Phospho-Tyr1162) antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.    

  
  

The Phospho-ErbB4 (Tyr1162) antibody is a specialized tool used to detect the activated form of ErbB4. a receptor tyrosine kinase belonging to the epidermal growth factor receptor (EGFR) family. ErbB4 plays critical roles in cell proliferation, differentiation, and survival, with signaling pathways implicated in development, tissue homeostasis, and diseases such as cancer and cardiovascular disorders. Upon ligand binding (e.g., neuregulins), ErbB4 undergoes dimerization and autophosphorylation at specific tyrosine residues, including Tyr1162. which serves as a docking site for downstream signaling adaptors like PI3K or Shc. This phosphorylation event is essential for initiating intracellular signaling cascades, such as the MAPK/ERK and PI3K/Akt pathways, which regulate diverse cellular responses.

The Phospho-ErbB4 (Tyr1162) antibody specifically recognizes the phosphorylated tyrosine residue at position 1162. enabling researchers to assess ErbB4 activation status in experimental models. It is widely utilized in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study ErbB4 signaling dynamics in physiological and pathological contexts. Dysregulation of ErbB4 phosphorylation has been linked to cancer progression, heart development defects, and neurological disorders, making this antibody valuable for both basic research and translational studies. Its applications extend to evaluating therapeutic interventions targeting ErbB4 pathways or validating biomarkers in disease models. Proper controls, such as total ErbB4 detection and phosphorylation inhibition assays, are recommended to ensure specificity in experimental workflows.