Phospho-KIF22 (Ser427)抗体;Phospho-KIF22 (Ser427) Antibody—艾普蒂

+ +

•  

   

     Western blot analysis of Phospho-KIF22 (Ser427) in A549, HL-60, U2OS lysates using Phospho-KIF22 (Ser427) antibody.    

  
  

Phospho-KIF22 (Ser427) antibody is a specialized tool used to detect the phosphorylated form of KIF22 at serine residue 427. KIF22. a member of the kinesin-like protein family, plays a critical role in mitotic processes, including chromosome alignment and spindle dynamics. Its activity is tightly regulated by post-translational modifications, particularly phosphorylation. The phosphorylation of KIF22 at Ser427 is mediated by cyclin-dependent kinase 1 (CDK1) during mitosis, which is essential for its proper function in chromosome segregation. Dysregulation of KIF22 phosphorylation has been implicated in mitotic errors, genomic instability, and cancer progression.

This antibody is widely used in research to study cell cycle regulation, mitotic mechanisms, and cancer biology. It enables the detection of phosphorylated KIF22 in various applications, such as Western blotting, immunofluorescence, and immunohistochemistry. Researchers employ it to investigate how phosphorylation at Ser427 influences KIF22’s interaction with microtubules, its role in spindle assembly, and its potential as a biomarker in cancers where KIF22 is overexpressed or aberrantly activated. Specificity validation via knockout/knockdown controls or phosphatase treatment is recommended to confirm target recognition. Understanding KIF22 phosphorylation dynamics provides insights into mitotic regulation and therapeutic strategies targeting cell division abnormalities.