Phospho-RSK2 (Ser227)抗体;Phospho-RSK2 (Ser227) Antibody—艾普蒂

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     Western blot analysis of Phospho-Rsk 2/MAPKAP Kinase 1b (Ser227) in C6, C6+UV lysates using Phospho-RSK2 (Ser227) antibody.    

  
  

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     Western blot analysis of Phospho-Rsk 2/MAPKAP Kinase 1b (Ser227) in 3T3, Hela lysates using Phospho-Rsk 2/MAPKAP Kinase 1b (Ser227) antibody.    

  
  

The Phospho-RSK2 (Ser227) antibody is a specialized tool used to detect the activated form of Ribosomal S6 Kinase 2 (RSK2), a serine/threonine kinase belonging to the RSK family. RSK2 plays a critical role in cell survival, proliferation, and growth by integrating signals from the MAPK/ERK pathway. Its activation typically occurs through sequential phosphorylation events: ERK1/2 first phosphorylates RSK2 at Thr577. enabling autophosphorylation at Ser227 within the kinase domain. Phosphorylation at Ser227 is essential for RSK2’s catalytic activity, allowing it to phosphorylate downstream targets like CREB, NF-κB, and histone H3. thereby regulating gene expression and cellular responses.

This antibody specifically recognizes RSK2 when phosphorylated at Ser227. making it valuable for studying RSK2 activation in response to growth factors, hormones, or stress signals. Researchers use it in techniques like Western blotting, immunofluorescence, or immunohistochemistry to assess RSK2 activity in cell lines, tissues, or disease models. Dysregulated RSK2 signaling is implicated in cancers, neurological disorders (e.g., Coffin-Lowry syndrome), and metabolic diseases, underscoring the antibody’s relevance in both basic research and therapeutic development. By detecting Ser227 phosphorylation, this antibody helps elucidate RSK2’s role in signaling networks and its potential as a biomarker or drug target.