Acetyl-Histone H2B (Lys15)抗体;Acetyl-Histone H2B (Lys15) Antibody—艾普蒂 新品

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     Western blot analysis of PMCA1 expression in HepG2 cell lysate.    

  
  

The Acetyl-Histone H2B (Lys15) antibody is a specialized tool used to detect the acetylation of lysine 15 (K15) on histone H2B, a post-translational modification (PTM) associated with chromatin remodeling and transcriptional regulation. Histones, including H2B, are core components of nucleosomes, which compact DNA into chromatin. Post-translational modifications such as acetylation, methylation, or phosphorylation dynamically alter chromatin structure, influencing gene expression by modulating DNA accessibility. Acetylation of histones, including H2B at K15. is generally linked to transcriptional activation, as it neutralizes the positive charge on lysine residues, reducing histone-DNA interactions and promoting an open chromatin state. This modification is regulated by histone acetyltransferases (HATs) and deacetylases (HDACs).

The Acetyl-Histone H2B (Lys15) antibody is widely used in epigenetic research to study site-specific acetylation patterns in processes like DNA repair, replication, and cell differentiation. It enables detection via techniques such as Western blotting, immunofluorescence, or chromatin immunoprecipitation (ChIP). Dysregulation of histone acetylation is implicated in diseases like cancer, making this antibody valuable for exploring epigenetic mechanisms in pathology or therapeutic contexts. Specificity for K15 acetylation ensures precise identification of this modification, distinguishing it from other histone marks. Researchers utilize it to investigate crosstalk between H2B acetylation and other histone modifications, as well as its role in maintaining genomic stability or regulating developmental pathways.