PEX11B抗体;PEX11B Antibody—艾普蒂

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     Western blot analysis of PEX11B expression in HT-29 cell lysate.    

  
  

The PEX11B antibody is a crucial tool for studying peroxisome dynamics and associated disorders. PEX11B (Peroxisomal Biogenesis Factor 11 Beta) is a membrane protein essential for peroxisome proliferation, fission, and maintenance. It belongs to the PEX11 family (PEX11α, β, γ) and plays a key role in shaping peroxisomal membranes and regulating their abundance in response to metabolic demands. Dysfunctions in PEX11B are linked to peroxisome biogenesis disorders (PBDs), such as Zellweger spectrum disorders, characterized by neurological impairments and metabolic abnormalities.

Researchers use PEX11B antibodies primarily in techniques like Western blotting, immunofluorescence, and immunohistochemistry to detect protein expression levels, subcellular localization, and morphological changes in peroxisomes. These studies help elucidate PEX11B's interaction with other peroxins (e.g., PEX19. PEX16) and its role in membrane elongation during peroxisome division. The antibody also aids in investigating disease mechanisms, including lipid metabolism defects and oxidative stress responses. Commercial PEX11B antibodies are typically validated in human, mouse, or rat samples, with specificity confirmed via knockout controls. Recent applications extend to cancer research, as altered peroxisome activity is observed in某些 tumors, highlighting its multifaceted relevance in cell biology and pathology.