ITPK1抗体;ITPK1 Antibody—艾普蒂

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     Western blot analysis of ITPK1 expression in HepG2 cell lysate.    

  
  

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     All lanes use the Antibody at 1:1k dilution for 1 hour at room temperature.    

  
  

**Background of ITPK1 Antibody**

The inositol trisphosphate 3-kinase 1 (ITPK1) antibody is a tool used to detect and study the ITPK1 protein, which plays a critical role in inositol phosphate metabolism. ITPK1 is an enzyme that phosphorylates inositol 1.4.5-trisphosphate (IP3) to generate inositol 1.3.4.5-tetrakisphosphate (IP4), a key step in regulating intracellular calcium signaling and cellular processes such as apoptosis, immune response, and gene expression. Dysregulation of ITPK1 has been implicated in diseases like cancer, neurodegenerative disorders, and inflammatory conditions.

ITPK1 antibodies are typically developed in host species (e.g., rabbits, mice) using immunogenic peptides or recombinant ITPK1 protein. These antibodies are validated for specificity and functionality in applications like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and ELISA. Researchers utilize ITPK1 antibodies to investigate its expression patterns, subcellular localization, and interactions with signaling pathways, such as the Wnt/β-catenin cascade.

The antibody’s importance lies in its role as a molecular probe to unravel ITPK1’s physiological and pathological mechanisms. Recent studies highlight its potential as a therapeutic target, particularly in cancers where ITPK1 modulates cell proliferation and survival. Quality validation, including knockout controls and cross-reactivity checks, ensures reliable experimental outcomes, making ITPK1 antibodies essential for advancing research in cell signaling and disease biology.