Glyt2抗体;Glyt2 Antibody—艾普蒂

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     Western blot analysis of Glyt2 expression in SH-SY5Y cell lysate.    

  
  

The glycine transporter 2 (GlyT2), encoded by the *SLC6A5* gene, is a sodium- and chloride-dependent neurotransmitter transporter primarily expressed in presynaptic terminals of inhibitory glycinergic neurons in the central nervous system. It plays a critical role in regulating synaptic glycine levels by mediating its reuptake, thereby terminating glycinergic signaling and maintaining neurotransmitter homeostasis. GlyT2 is essential for normal motor coordination, pain processing, and respiratory rhythms, with dysfunction linked to neurological disorders such as hyperekplexia (startle disease), chronic pain syndromes, and potentially neuropsychiatric conditions.

GlyT2-specific antibodies are vital tools for studying the distribution, expression, and functional dynamics of this transporter in both physiological and pathological contexts. These antibodies enable the visualization of GlyT2 in brain and spinal cord tissues via immunohistochemistry, Western blotting, or immunofluorescence, aiding research into glycinergic circuit organization. Additionally, they are used to investigate GlyT2 trafficking, post-translational modifications, and interactions with therapeutic agents, including inhibitors explored for analgesic applications. Recent studies also utilize GlyT2 antibodies to validate animal models of glycinergic dysfunction and assess therapeutic interventions targeting glycinergic transmission. Their specificity and reliability remain crucial for advancing understanding of GlyT2's role in health and disease.