PPCS抗体;PPCS Antibody—艾普蒂

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     Western blot analysis of PPCS expression in SH-SY5Y cell lysate.    

  
  

**Background of PPCS Antibody**

The PPCS (phosphopantothenoylcysteine synthetase) antibody is a tool used to detect and study the PPCS enzyme, a critical component in the coenzyme A (CoA) biosynthesis pathway. PPCS catalyzes the second step of CoA synthesis, converting pantothenate (vitamin B5) into 4'-phosphopantothenoylcysteine, a precursor essential for CoA production. CoA is a central cofactor in cellular metabolism, influencing fatty acid synthesis, energy production (via the tricarboxylic acid cycle), and detoxification processes.

Research involving PPCS antibodies focuses on understanding CoA regulation and its implications in metabolic disorders, neurodegenerative diseases, and cancer. Dysregulation of CoA levels has been linked to conditions such as neurodegeneration (e.g., Parkinson’s disease) and tumor growth, where altered metabolic pathways are common. PPCS antibodies enable the detection of PPCS expression in tissues or cell lines via techniques like Western blotting, immunohistochemistry, or immunofluorescence, aiding in mechanistic studies of CoA-related pathologies.

Additionally, PPCS is explored in microbial biology, as pathogens like *Plasmodium* (malaria parasite) rely on their CoA synthesis pathways for survival, making PPCS a potential therapeutic target. The development and validation of PPCS antibodies thus contribute to both basic research and drug discovery, bridging gaps in metabolic and disease biology.