PLSCR3抗体;PLSCR3 Antibody—艾普蒂

+ +

•  

   

     Western blot analysis of PLSCR3 expression in BxPC 3 cell lysate.    

  
  

The phospholipid scramblase 3 (PLSCR3) antibody is a tool used to detect and study the PLSCR3 protein, a member of the phospholipid scramblase family. PLSCR3 is a mitochondrial membrane-associated protein implicated in lipid transport, membrane dynamics, and cellular signaling. Unlike other scramblases (e.g., PLSCR1), PLSCR3 does not exhibit calcium-dependent scrambling activity but plays a role in maintaining mitochondrial architecture, apoptosis regulation, and interactions with mitochondrial proteins like cardiolipin. Its expression is linked to cellular stress responses, cancer progression, and immune modulation, though its precise mechanisms remain under investigation.

PLSCR3 antibodies are typically developed in hosts like rabbits or mice using immunogenic peptides or recombinant PLSCR3 protein. These antibodies enable researchers to analyze PLSCR3 expression, localization, and function via techniques such as Western blotting, immunofluorescence, and immunoprecipitation. Validated antibodies show specificity for PLSCR3 without cross-reactivity to other scramblases. Dysregulation of PLSCR3 has been observed in cancers, neurodegenerative disorders, and metabolic diseases, making its study relevant for understanding disease mechanisms. Commercial PLSCR3 antibodies are widely used in basic research, often accompanied by validation data (e.g., knockout controls) to ensure reliability. Ongoing research aims to clarify PLSCR3's role in mitochondrial quality control and its potential as a therapeutic target.