CTPsynthase/CTPS抗体;CTPsynthase/CTPS Antibody—艾普蒂 新品

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     Western blot analysis of CTP synthase / CTPS expression in HeLa cell lysate.    

  
  

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     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

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     All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    

  
  

CTP synthase (CTPS) is a metabolic enzyme that catalyzes the conversion of uridine triphosphate (UTP) to cytidine triphosphate (CTP), the final step in de novo pyrimidine biosynthesis. This ATP-dependent reaction is critical for nucleotide metabolism, supporting DNA/RNA synthesis and cellular proliferation. CTPS activity is tightly regulated and often upregulated in rapidly dividing cells, including cancer cells, making it a potential therapeutic target. Antibodies targeting CTPS are widely used in research to study its expression, localization, and regulatory mechanisms under physiological or pathological conditions.

CTPS antibodies are employed in techniques like Western blotting, immunofluorescence, and immunohistochemistry to assess protein levels in tissues or cell lines, particularly in cancer, immune disorders, or viral infection studies. Some antibodies detect specific post-translational modifications (e.g., phosphorylation) that modulate CTPS activity or filament formation—a unique structural feature linked to enzyme regulation. Additionally, these antibodies help investigate CTPS inhibitors in preclinical models, exploring their impact on nucleotide depletion and cell cycle arrest. Recent studies also highlight CTPS’s role in immune cell function and antiviral responses, expanding the antibody’s utility in immunometabolism research. Validation of CTPS antibodies includes testing in knockout models or enzyme activity assays to ensure specificity, given homology with other glutamine-dependent amidotransferases.