RBM3抗体;RBM3 Antibody—艾普蒂

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     Western blot analysis of RBM3 expression in Jurkat cell lysate.    

  
  

The RNA Binding Motif Protein 3 (RBM3) antibody is a tool used to study RBM3. a cold-shock protein belonging to the glycine-rich RNA-binding protein family. RBM3 is evolutionarily conserved and plays a role in RNA metabolism, including splicing, stabilization, and translation regulation. It is induced under hypothermic conditions, where it promotes cell survival by inhibiting apoptosis and maintaining protein synthesis. RBM3 is also implicated in stress granule formation during cellular stress, such as hypoxia or nutrient deprivation.

In research, RBM3 has garnered attention for its dual roles in cancer and neuroprotection. Studies suggest it may act as an oncogene in certain cancers (e.g., breast, prostate) by enhancing cell proliferation and chemoresistance, while its neuroprotective effects in Alzheimer’s and Parkinson’s disease models highlight its role in synaptic plasticity and neuronal survival. The RBM3 antibody is widely used in techniques like immunohistochemistry, Western blotting, and immunofluorescence to detect RBM3 expression in tissues or cultured cells, aiding in biomarker discovery and mechanistic studies. However, conflicting data on its prognostic value in cancer underscore the need for context-specific analysis. Recent interest also explores its therapeutic potential in hypothermia-mediated neuroprotection and cancer therapy resistance.