SRP19抗体;SRP19 Antibody—艾普蒂

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     Western blot analysis of SRP19 expression in HeLa cell lysate.    

  
  

The SRP19 antibody is a research tool used to study the Signal Recognition Particle (SRP) 19 kDa protein, a critical component of the SRP complex. SRP is a ribonucleoprotein complex essential for co-translational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP19. a conserved RNA-binding protein, stabilizes the SRP RNA scaffold by binding to its Alu domain and facilitates the assembly of SRP54. the key subunit responsible for recognizing signal sequences on nascent polypeptides. Dysregulation of SRP-mediated protein translocation is linked to cellular stress, developmental disorders, and diseases like cancer.

SRP19 antibodies are primarily used in molecular biology to investigate SRP assembly, RNA-protein interactions, and ER targeting mechanisms. They enable detection and quantification of SRP19 via techniques like Western blotting, immunofluorescence, and immunoprecipitation. Researchers also utilize these antibodies to explore SRP19's role in pathological contexts, such as tumor progression or rare genetic disorders affecting protein secretion. Commercial SRP19 antibodies are typically raised in rabbits or mice, validated for specificity against recombinant or endogenous proteins.

Understanding SRP19's function through antibody-based studies provides insights into fundamental cellular processes and potential therapeutic strategies for diseases involving defective protein trafficking.