LTB4R抗体;LTB4R Antibody—艾普蒂 新品

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     Western blot analysis of LTB4R expression in A549 cell lysate.    

  
  

The leukotriene B4 receptor (LTB4R), also known as BLT1. is a G protein-coupled receptor (GPCR) that binds leukotriene B4 (LTB4), a potent lipid mediator derived from arachidonic acid. LTB4R plays a critical role in inflammatory and immune responses by mediating chemotaxis, degranulation, and cytokine release in neutrophils, macrophages, and T cells. Its activation is linked to chronic inflammatory diseases, including asthma, rheumatoid arthritis, atherosclerosis, and psoriasis, making it a therapeutic target for anti-inflammatory drug development.

LTB4R antibodies are essential tools for studying receptor expression, localization, and signaling mechanisms. They are widely used in techniques such as Western blotting, immunohistochemistry (IHC), and flow cytometry to investigate LTB4R distribution in tissues or cell lines under pathological conditions. Some antibodies block LTB4 binding, serving as antagonists to study receptor-ligand interactions or evaluate therapeutic candidates. Recent research also explores LTB4R's role in cancer progression and metabolic disorders, expanding its relevance beyond classical inflammation. Commercial LTB4R antibodies are typically raised against extracellular or intracellular epitopes, with validation focusing on specificity (e.g., using knockout controls) and functional applications. Challenges include distinguishing between LTB4R isoforms and ensuring cross-reactivity across species in preclinical models.