TUB1抗体;TUB1 Antibody—艾普蒂 新品

TUB1 antibody is a research tool targeting the TUB1 protein, a member of the α-tubulin family. Tubulins are essential structural components of microtubules, dynamic cytoskeletal polymers involved in cell division, intracellular transport, and maintenance of cell shape. In eukaryotes, α-tubulin isoforms like TUB1 exhibit tissue-specific expression patterns and functional specializations. For instance, TUB1 is prominently expressed in neurons and is implicated in neuronal development, axon guidance, and synaptic plasticity. The antibody is commonly generated in hosts like rabbits or mice using immunogenic peptides or recombinant TUB1 protein. It enables the detection and localization of TUB1 in techniques such as Western blotting, immunofluorescence, and immunohistochemistry. Researchers use TUB1 antibodies to study microtubule dynamics, neuronal differentiation, and diseases linked to tubulin dysfunction, such as neurodegenerative disorders and cancer. Specificity validation via knockout controls or siRNA knockdown is critical, as cross-reactivity with other α-tubulin isoforms (e.g., TUB3. TUB4) may occur. Commercial TUB1 antibodies often cite applications in model organisms, including mammals and yeast, reflecting its evolutionary conservation. Recent studies also explore its role in cilia formation and cellular responses to microtubule-targeting drugs. Proper experimental controls remain essential to ensure data accuracy.