COASY抗体;COASY Antibody—艾普蒂

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     Western blot analysis of COASY expression in HeLa cell lysate.    

  
  

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     All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    

  
  

**Background of COASY Antibody**

COASY (Coenzyme A Synthase) is a bifunctional enzyme critical for the final steps of coenzyme A (CoA) biosynthesis, catalyzing the phosphorylation of pantetheine to form phosphopantetheine and subsequent adenylation to generate dephospho-CoA. CoA is an essential cofactor involved in numerous metabolic pathways, including fatty acid synthesis, the tricarboxylic acid (TCA) cycle, and neurotransmitter production. Dysregulation of CoA metabolism has been linked to neurodegenerative disorders, mitochondrial dysfunction, and metabolic diseases.

COASY antibodies are immunological tools designed to detect and quantify COASY protein levels in research applications. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study COASY expression, localization, and interactions in cellular or tissue samples. These antibodies have also facilitated investigations into COASY's role in cellular energy homeostasis, neuroprotection, and disease mechanisms. For instance, studies using COASY antibodies have explored its involvement in Parkinson’s disease, where CoA deficiency may impair neuronal viability.

As COASY consists of two functional domains (phosphopantetheine adenylyltransferase and dephospho-CoA kinase), specific antibodies targeting distinct epitopes help dissect its structural and functional dynamics. Validated COASY antibodies are crucial for ensuring accuracy in experimental models, advancing both basic research and therapeutic targeting of CoA-related pathologies.