GLU2B抗体;GLU2B Antibody—艾普蒂

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     Western blot analysis of GLU2B expression in A431 cell lysate.    

  
  

The GLU2B antibody targets the GluN2B subunit (also known as NR2B) of the N-methyl-D-aspartate (NMDA) receptor, a critical ionotropic glutamate receptor in the central nervous system. NMDA receptors are heterotetrameric complexes typically composed of two GluN1 subunits and two GluN2 subunits (GluN2A-D), with GluN2B being predominant in early development and enriched in forebrain regions. This subunit plays a key role in synaptic plasticity, learning, and memory by regulating calcium influx and downstream signaling pathways.

GLU2B antibodies are widely used in neuroscience research to study receptor localization, expression levels, and post-translational modifications (e.g., phosphorylation) in physiological and pathological contexts. They are essential tools for investigating neurological disorders such as Alzheimer’s disease, stroke, and epilepsy, where GluN2B dysfunction is implicated. Specific GLU2B antibodies can distinguish between phosphorylated or truncated isoforms, aiding in the analysis of receptor trafficking and activity-dependent changes.

These antibodies are validated for techniques like Western blotting, immunohistochemistry, and immunofluorescence, often in combination with models of neurotoxicity or genetic manipulation. Their application has advanced understanding of NMDA receptor biology, synaptic transmission mechanisms, and potential therapeutic targets for neuropsychiatric conditions.