CRMP3抗体;CRMP3 Antibody—艾普蒂 新品

+ +

•  

   

     Western blot analysis of CRMP3 expression in SH-SY5Y cell lysate.    

  
  

CRMP3 (Collapsin Response Mediator Protein 3), also known as DPYSL4. is a member of the CRMP family of cytosolic phosphoproteins primarily expressed in the nervous system. These proteins play critical roles in neuronal development, including axon guidance, dendritic patterning, and synaptic plasticity by regulating microtubule dynamics and intracellular signaling pathways. CRMP3 interacts with tubulin heterodimers to promote microtubule assembly, influencing neurite outgrowth and neuronal polarity. It is particularly abundant in the developing brain but remains expressed in specific regions of the adult brain, such as the hippocampus and cerebellum.

CRMP3 antibodies are widely used as research tools to study its expression, localization, and function in neurological processes. Dysregulation of CRMP3 has been implicated in neurodevelopmental disorders, neurodegenerative diseases (e.g., Alzheimer’s), and psychiatric conditions. For example, reduced CRMP3 levels correlate with synaptic deficits in Alzheimer’s models. Antibodies against CRMP3 also help investigate its role in cancer, where aberrant expression is observed in glioblastoma and neuroblastoma.

These antibodies are essential for techniques like Western blotting, immunohistochemistry, and immunofluorescence, enabling researchers to explore CRMP3's involvement in Semaphorin 3A signaling and its cross-talk with pathways like GSK-3β. Their specificity and reliability make them valuable for deciphering CRMP3’s contributions to both physiological and pathological states.