Olig3抗体;Olig3 Antibody—艾普蒂

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     Western blot analysis of Olig3 expression in 293T cell lysate.    

  
  

The Olig3 antibody targets Olig3. a member of the Olig family of basic helix-loop-helix (bHLH) transcription factors. Olig3 is primarily expressed in the developing nervous system, particularly within progenitor domains of the rhombic lip and dorsal ventricular zone in the hindbrain and cerebellum. It plays a critical role in patterning and specifying neuronal subtypes during embryogenesis, especially in the brainstem and spinal cord. Olig3 is involved in regulating the differentiation of glutamatergic and GABAergic neuronal precursors, contributing to the establishment of neural circuits.

Studies highlight its importance in the formation of precerebellar nuclei and dorsal spinal cord interneurons. Dysregulation of Olig3 has been implicated in neurodevelopmental disorders and certain brain tumors, such as medulloblastoma, where its expression may correlate with tumor subtype and prognosis. The Olig3 antibody is widely used in research to identify and study neural progenitor populations, track developmental trajectories, and investigate mechanisms underlying neural patterning.

As a research tool, it aids in immunohistochemistry, immunofluorescence, and Western blotting, enabling visualization of Olig3 expression patterns in tissue sections or cell cultures. Its specificity and reliability make it valuable for exploring the molecular basis of neural development and disease. Recent work continues to uncover its interactions with other transcription factors, shedding light on its role in maintaining progenitor cell identity and regulating lineage commitment.