CathepsinH抗体;CathepsinH Antibody—艾普蒂 新品

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     Western blot analysis of Cathepsin H in HepG2  cell lysate.    

  
  

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     All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    

  
  

Cathepsin H antibody is a key tool in studying the function and expression of cathepsin H, a lysosomal cysteine protease belonging to the papain family. Cathepsin H plays critical roles in protein turnover, antigen processing, and extracellular matrix remodeling by cleaving peptide bonds under acidic conditions. Unlike other cathepsins, it exhibits both endopeptidase and aminopeptidase activities due to its unique mini-chain structure, which regulates substrate specificity. Dysregulation of cathepsin H has been implicated in pathological processes, including cancer progression, neurodegenerative diseases (e.g., Alzheimer’s), and inflammatory disorders. Its overexpression in tumors is associated with enhanced invasion, metastasis, and angiogenesis.

Cathepsin H antibodies are widely used in research to detect protein expression and localization via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). These antibodies help elucidate its role in lysosomal storage disorders, immune response modulation, and tissue homeostasis. Monoclonal antibodies offer high specificity, while polyclonal versions may detect broader epitopes. Validation methods, such as knockout controls or peptide blocking, ensure antibody reliability. Species reactivity typically includes human, mouse, and rat samples. Recent studies also explore cathepsin H as a biomarker or therapeutic target, driving demand for well-characterized antibodies. Researchers prioritize antibodies with minimal cross-reactivity to related proteases (e.g., cathepsin B/L) to avoid false interpretations. Overall, cathepsin H antibodies remain essential for advancing understanding of lysosomal biology and disease mechanisms.