Themis抗体;Themis Antibody—艾普蒂 新品

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     Western blot analysis of Themis expression in Jurkat cell lysate.    

  
  

Themis antibodies are tools used to study the Themis protein family, which plays a critical role in immune system regulation, particularly in T-cell development and signaling. Themis proteins (Themis1 and Themis2) were identified in the early 2010s as key modulators of T-cell receptor (TCR) signaling pathways. They are predominantly expressed in thymocytes and mature T cells, where they influence positive and negative selection during T-cell maturation in the thymus. This process ensures immune tolerance and prevents autoimmune reactions.

Structurally, Themis proteins contain conserved domains, such as a proline-rich region and a CABIT (cysteine-containing, all-alpha) domain, which mediate interactions with signaling molecules like SHP1 phosphatase. Themis1. for example, acts as a scaffold to regulate TCR signal strength, balancing activation and inhibition to ensure proper immune responses.

Antibodies targeting Themis are used in research to explore its function in immune diseases, cancer, and autoimmune disorders. Studies using Themis knockout models have linked its absence to dysregulated T-cell development and increased susceptibility to autoimmunity. These antibodies enable techniques like Western blotting, flow cytometry, and immunohistochemistry, aiding mechanistic insights into TCR signaling dynamics and potential therapeutic targets.

Overall, Themis antibodies are vital for dissecting immune regulation mechanisms and their implications in health and disease.