BAT3抗体;BAT3 Antibody—艾普蒂 新品

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     Western blot analysis of BAT3 expression in A431 cell lysate.    

  
  

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     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

**Background of BAT3 Antibody**

BAT3 (HLA-B-associated transcript 3), also known as BAG6 or Scythe, is a multifunctional protein involved in protein quality control, apoptosis regulation, and immune response. As a member of the BAG (Bcl-2-associated athanogene) protein family, it plays a critical role in ubiquitin-mediated proteolysis, endoplasmic reticulum-associated degradation (ERAD), and chaperoning nascent or misfolded proteins. BAT3 interacts with components of the ubiquitin-proteasome system and facilitates the degradation of defective polypeptides, ensuring cellular homeostasis.

In cancer biology, BAT3 has dual roles, acting as a tumor suppressor by promoting apoptosis under stress conditions or as an oncogenic factor supporting metastasis and immune evasion. It is also implicated in neurodegenerative diseases linked to protein aggregation. BAT3 antibodies are essential tools for detecting and studying the protein’s expression, localization, and interactions in these contexts. They are widely used in techniques like Western blotting, immunohistochemistry, and co-immunoprecipitation to explore BAT3’s involvement in DNA damage repair, viral infection responses, and MHC class I antigen presentation.

Research using BAT3 antibodies has highlighted its potential as a biomarker or therapeutic target in cancers and neurodegenerative disorders, emphasizing its regulatory versatility in cellular stress pathways.