APLP2抗体;APLP2 Antibody—艾普蒂

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     Western blot analysis of APLP2 expression in HeLa cell lysate.    

  
  

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     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

The amyloid precursor-like protein 2 (APLP2) is a transmembrane glycoprotein belonging to the conserved amyloid precursor protein (APP) family, which includes APP and APLP1. While APLP2 shares structural and functional similarities with APP—a key player in Alzheimer’s disease (AD) pathogenesis—it lacks the amyloid-beta (Aβ) domain critical for forming neurotoxic plaques. APLP2 is ubiquitously expressed, with high levels in the brain, lungs, and muscles, and is implicated in cell adhesion, synaptic maintenance, and metal ion homeostasis. Studies suggest its role in neuronal outgrowth, calcium signaling, and interactions with synaptic proteins like neurexins.

APLP2-specific antibodies are vital tools for investigating its biological functions and disease associations. Researchers use these antibodies in techniques such as Western blotting, immunohistochemistry, and co-immunoprecipitation to study APLP2 expression, localization, and protein interactions. Unlike APP, APLP2 does not generate Aβ, but its knockout in mice causes synaptic defects and postnatal lethality, highlighting its essential role in development. In AD research, APLP2 antibodies help delineate pathways shared with APP, offering insights into non-amyloid mechanisms of neurodegeneration. Additionally, APLP2 has been linked to cancer progression, with antibodies aiding in exploring its oncogenic potential. Despite overlapping roles with APP/APLP1. APLP2’s unique regulatory features make it a distinct therapeutic and diagnostic target.