Neurocan抗体;Neurocan Antibody—艾普蒂 新品

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     Western blot analysis of Neurocan expression in Fetal brain cell lysate.    

  
  

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     Immunoprecipitate (IP) analysis using the Antibody at 1:50 dilution. (wb at 1:3K dilution)    

  
  

Neurocan antibodies are essential tools in neuroscience research, specifically targeting neurocan, a chondroitin sulfate proteoglycan (CSPG) predominantly expressed in the central nervous system (CNS). Neurocan, a member of the lectican family, plays critical roles during brain development by regulating neuronal migration, axon guidance, and synaptic plasticity. It is highly abundant in the extracellular matrix (ECM) of developing brains but decreases in adulthood, though its expression can be upregulated following CNS injury or in neurodegenerative conditions like Alzheimer’s or Parkinson’s disease. Neurocan interacts with other ECM components and cell surface receptors, influencing cell adhesion and signaling pathways.

Antibodies against neurocan enable researchers to detect and study its spatial-temporal distribution, functional interactions, and involvement in pathological processes. They are widely used in techniques such as immunohistochemistry, Western blotting, and immunofluorescence to visualize neurocan in tissue sections or cultured cells. These antibodies have been instrumental in exploring neurocan’s dual role: while it inhibits axonal regeneration post-injury by creating a growth-restrictive environment, it also supports neuroprotection and ECM remodeling. Additionally, neurocan antibodies aid in investigating its potential as a biomarker for neurological disorders and in evaluating therapeutic strategies targeting CSPGs to enhance neural repair. Most neurocan antibodies are raised against specific epitopes in its core protein, ensuring specificity across species like humans, mice, and rats.