TMOD2抗体;TMOD2 Antibody—艾普蒂

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     Western blot analysis of TMOD2 expression in SH-SY5Y cell lysate.    

  
  

**Background of TMOD2 Antibody**

The TMOD2 (Tropomodulin 2) antibody is a tool used to study the Tropomodulin family, specifically targeting the TMOD2 isoform, which is predominantly expressed in the central nervous system (CNS), particularly in neurons. TMOD2 is a key regulator of actin filament dynamics, playing a critical role in stabilizing the cytoskeleton by capping actin filaments at their pointed ends. This function is essential for maintaining neuronal morphology, synaptic plasticity, and dendritic spine development.

Research involving TMOD2 antibodies focuses on understanding its role in neurodevelopment, synaptic function, and neurodegenerative disorders. Studies link TMOD2 dysregulation to conditions like Alzheimer’s disease and intellectual disabilities, highlighting its importance in neuronal health. The antibody is commonly used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to detect TMOD2 expression, localization, and interaction with cytoskeletal proteins.

TMOD2 antibodies are often validated for specificity against its unique N-terminal domain, distinguishing it from other Tropomodulin isoforms (e.g., TMOD1. TMOD3). Their application aids in elucidating mechanisms of actin-dependent processes in neurons and glial cells, offering insights into CNS pathophysiology and potential therapeutic targets.