TIMM50抗体;TIMM50 Antibody—艾普蒂

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     Western blot analysis of TIMM50 expression in 293T cell lysate.    

  
  

The TIMM50 antibody is designed to target the Translocase of Inner Mitochondrial Membrane 50 (TIMM50), a key component of the mitochondrial protein import machinery. TIMM50 is a subunit of the TIM23 complex, which mediates the translocation of presequence-containing proteins from the mitochondrial intermembrane space into the matrix. This process is critical for maintaining mitochondrial function, including oxidative phosphorylation, metabolic regulation, and apoptosis. TIMM50 acts as a receptor, recognizing precursor proteins and facilitating their transport across the inner mitochondrial membrane, while also stabilizing the TIM23 complex structure.

Dysregulation of TIMM50 has been linked to mitochondrial disorders, neurodegenerative diseases, and cancer, as impaired protein import disrupts cellular energy production and signaling pathways. Studies suggest TIMM50 deficiency may contribute to Parkinson’s disease pathology and tumor progression by promoting mitochondrial dysfunction. Researchers utilize TIMM50 antibodies in techniques like Western blotting, immunofluorescence, and immunohistochemistry to investigate its expression, localization, and interactions in disease models or under stress conditions. These studies aim to elucidate TIMM50’s role in mitochondrial health and its potential as a therapeutic target. The antibody’s specificity and validation across applications make it a vital tool for advancing mitochondrial biology research.