Timeless抗体;Timeless Antibody—艾普蒂 新品

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     Western blot analysis of Timeless expression in HeLa cell lysate.    

  
  

**Background of Timeless Antibody**

The Timeless protein, a conserved component of the DNA replication machinery, plays a critical role in maintaining genome stability by facilitating DNA replication and repair. It interacts with partners like TIPIN and Claspin to form the replication fork protection complex, which stabilizes stalled replication forks during replication stress. Dysregulation of Timeless is linked to genomic instability, a hallmark of cancer and other diseases.

Timeless antibodies are essential tools for studying its function, localization, and expression in cellular contexts. Researchers use these antibodies in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate Timeless' role in cell cycle regulation, replication fork dynamics, and the DNA damage response. Elevated Timeless levels have been observed in various cancers, correlating with poor prognosis, suggesting its potential as a therapeutic target or biomarker.

Studies leveraging Timeless antibodies have also explored its interplay with checkpoint kinases (e.g., ATR, Chk1) and its involvement in circadian rhythm regulation, hinting at broader physiological impacts. Ongoing research aims to clarify its mechanisms in tumorigenesis and exploit Timeless inhibition for cancer therapy.

In summary, Timeless antibodies are pivotal for unraveling the protein's contributions to genome integrity and disease, offering insights into targeted treatment strategies.