Ube1L/UBA7抗体;Ube1L/UBA7 Antibody—艾普蒂 新品

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     Western blot analysis of Ube1L / UBA7 in HepG2  cell lysate.    

  
  

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     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

The Ube1L/UBA7 antibody is a critical tool for studying the ubiquitin-activating enzyme E1-like protein (Ube1L), also known as ubiquitin-like modifier-activating enzyme 7 (UBA7). UBA7 belongs to the E1 enzyme family, which initiates the ubiquitination and ubiquitin-like modification cascades by activating and transferring ubiquitin or ubiquitin-like proteins (e.g., ISG15) to E2 conjugating enzymes. Unlike the canonical UBA1. UBA7 is interferon (IFN)-inducible and primarily mediates ISG15 conjugation (ISGylation), a post-translational modification involved in antiviral responses, DNA repair, and cellular stress pathways.

Antibodies targeting UBA7 are widely used to investigate its expression, localization, and function in immune regulation, particularly in contexts of viral infection, autoimmune diseases, and cancer. Studies have linked UBA7 dysregulation to pathologies such as chronic inflammation and tumorigenesis, underscoring its role in maintaining cellular homeostasis. Researchers employ these antibodies in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess UBA7 protein levels, often in IFN-stimulated cells or disease models. Specificity is a key consideration, as UBA7 shares structural homology with other E1 enzymes. Validated antibodies help distinguish UBA7’s unique contributions to ISGylation and its crosstalk with the ubiquitin-proteasome system, advancing therapeutic strategies targeting protein modification pathways.