GTPBP4抗体;GTPBP4 Antibody—艾普蒂

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     Western blot analysis of GTPBP4 expression in Human fetal kidney lysate.    

  
  

The GTPBP4 antibody is a crucial tool for studying the GTP-binding protein 4 (GTPBP4), a conserved eukaryotic enzyme involved in ribosomal biogenesis and cellular translation. GTPBP4. also known as NOG1 (nucleolar GTPase 1), is a nucleolar protein that binds GTP and plays a role in the maturation and assembly of the 60S ribosomal subunit. It interacts with pre-ribosomal particles and facilitates rRNA processing, ensuring proper ribosome formation and function. Dysregulation of GTPBP4 has been linked to developmental disorders, cancer, and neurodegenerative diseases, highlighting its importance in cell proliferation and homeostasis.

The GTPBP4 antibody is typically produced in hosts like rabbits or mice, using immunogenic peptide sequences specific to conserved regions of the protein. It is widely used in techniques such as Western blotting, immunofluorescence, and immunoprecipitation to detect GTPBP4 expression, localization, and interaction partners. Validated for specificity, this antibody helps researchers explore GTPBP4’s role in ribosome biogenesis, its response to cellular stress, and its potential as a biomarker or therapeutic target. Commercial antibodies often include applications in human, mouse, or rat samples, supporting studies in cancer biology, developmental biology, and translational research.