Pleiotrophin抗体;Pleiotrophin Antibody—艾普蒂 新品

+ +

•  

   

     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

•  

   

     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

**Background of Pleiotrophin Antibodies**

Pleiotrophin (PTN), also known as heparin-binding growth-associated molecule (HB-GAM), is a secreted growth factor belonging to the heparin-binding cytokine family. It plays critical roles in embryonic development, tissue repair, and pathological processes such as tumorigenesis and neurodegeneration. PTN interacts with cell surface receptors, including receptor protein tyrosine phosphatase beta/zeta (RPTPβ/ζ) and anaplastic lymphoma kinase (ALK), modulating signaling pathways involved in cell proliferation, migration, angiogenesis, and neural plasticity.

Antibodies targeting PTN are essential tools for studying its expression, localization, and function. They enable detection of PTN in various biological samples (e.g., tissues, cell lysates) via techniques like Western blot, immunohistochemistry, and ELISA. PTN antibodies are widely used in cancer research, as PTN is overexpressed in glioblastoma, breast cancer, and other malignancies, promoting tumor progression and metastasis. Additionally, they aid in exploring PTN’s role in neurological disorders, such as Alzheimer’s disease, where PTN may influence amyloid-beta aggregation.

Researchers also utilize neutralizing PTN antibodies to inhibit its activity in experimental models, providing insights into therapeutic strategies. Validated antibodies with high specificity are crucial, as PTN shares structural homology with other growth factors like midkine. Commercial PTN antibodies are typically raised in rabbits or mice, with applications spanning basic research and drug development.