HistoneH3(acetylK23)抗体;HistoneH3(acetylK23) Antibody—艾普蒂 新品

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     All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    

  
  

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     All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    

  
  

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     All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    

  
  

The Histone H3 (acetylK23) antibody is a specialized tool used to detect acetylation at lysine 23 (K23) on histone H3. a post-translational modification critical for epigenetic regulation. Histones are core proteins around which DNA wraps to form nucleosomes, and their post-translational modifications, such as acetylation, influence chromatin structure and gene expression. Acetylation of histones, including H3K23. reduces the positive charge of lysine residues, weakening their interaction with negatively charged DNA. This loosens chromatin, promoting transcriptional activation by allowing access to transcription factors and regulatory proteins.

The acetylation of H3K23 is associated with active transcription, DNA repair, and cell cycle progression. It is dynamically regulated by histone acetyltransferases (HATs) and deacetylases (HDACs). Aberrant H3K23 acetylation has been implicated in diseases such as cancer, neurodegenerative disorders, and developmental defects, making its study vital for understanding disease mechanisms.

The Histone H3 (acetylK23) antibody is widely used in techniques like chromatin immunoprecipitation (ChIP), immunofluorescence, and Western blotting to map epigenetic changes, study gene regulation, or assess therapeutic responses targeting epigenetic modifiers. Its specificity for the acetylated K23 residue ensures accurate detection, distinguishing it from other acetylation sites on histone H3 (e.g., K9. K14. K18). Researchers rely on this antibody to explore links between chromatin dynamics, cellular processes, and disease pathology, highlighting its importance in epigenetics and molecular biology research.