Phospho-Tau(S214)抗体;Phospho-Tau(S214) Antibody—艾普蒂 新品

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     Western blot analysis of PGAM1 expression in A431 cell lysate.    

  
  

Phospho-Tau (S214) antibody is a specialized tool used to detect tau protein phosphorylated at serine residue 214 (Ser214), a post-translational modification implicated in neurodegenerative diseases. Tau, a microtubule-associated protein, stabilizes neuronal cytoskeleton by binding microtubules. Its hyperphosphorylation disrupts this interaction, leading to microtubule destabilization and pathological tau aggregation, hallmarks of Alzheimer’s disease (AD) and other tauopathies. Phosphorylation at Ser214 is mediated by kinases like PKA and CDK5. which are dysregulated in neurodegeneration. Studies suggest Ser214 phosphorylation may enhance tau’s propensity to aggregate or interfere with microtubule binding.

This antibody is widely used in research to study tau pathology in brain tissues, cell models, or transgenic animals. It helps assess disease progression, therapeutic responses, and mechanistic pathways in AD. Specificity for phospho-Ser214 enables differentiation from other phosphorylated tau forms, aiding in mapping phosphorylation patterns linked to pathology. Validation methods (e.g., Western blot, immunohistochemistry) ensure its reliability in detecting target epitopes. However, cross-reactivity with similar phospho-epitopes or non-specific binding requires careful experimental controls.

Overall, Phospho-Tau (S214) antibody serves as a critical reagent for understanding tau’s role in neurodegeneration and advancing diagnostic or therapeutic strategies targeting phosphorylated tau species.