FYB抗体;FYB Antibody—艾普蒂

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     Western blot analysis of FYB expression in TF-1 cell lysate.    

  
  

FYB (FYN-binding protein), also known as ADAP (Adhesion and Degranulation Promoting Adaptor Protein), is a cytoplasmic adaptor protein predominantly expressed in hematopoietic cells, particularly T cells and platelets. It was first identified in the 1990s through its interaction with FYN, a Src-family kinase involved in T-cell receptor (TCR) signaling. Structurally, FYB contains multiple protein interaction domains, including an SH3 domain-binding region and tyrosine phosphorylation sites, enabling its role in scaffolding signaling complexes.

FYB plays a critical role in TCR-mediated signaling, integrin activation, and immune synapse formation. It regulates cytoskeletal reorganization and cell adhesion by linking TCR activation to downstream effectors like SKAP1 and VAV1. In platelets, FYB contributes to integrin αIIbβ3 activation during thrombus formation. Dysregulation of FYB has been implicated in immune disorders, including autoimmune diseases and immunodeficiency syndromes, as well as platelet-related pathologies.

FYB-specific antibodies are essential tools for studying its expression, post-translational modifications, and interactions in immune signaling pathways. They enable applications such as Western blotting, immunoprecipitation, and immunofluorescence to explore FYB's functional dynamics in health and disease. Research on FYB continues to shed light on its dual roles in adaptive immunity and hemostasis.