TBX21抗体;TBX21 Antibody—艾普蒂

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     Immunohistochemical analysis of paraffin-embedded human spleen, using T-bet/Tbx21 Antibody.    

  
  

The TBX21 antibody targets the T-box transcription factor 21 (TBX21), also known as T-bet, a critical regulator of immune cell differentiation and function. TBX21. encoded by the *TBX21* gene, belongs to the T-box protein family characterized by a conserved DNA-binding domain. It is pivotal in driving the development of T-helper 1 (Th1) cells by promoting interferon-gamma (IFN-γ) production and suppressing Th2 lineage commitment. TBX21 is expressed in immune cells, including CD4+ T cells, natural killer (NK) cells, and dendritic cells, where it modulates cytokine profiles and effector functions.

Antibodies against TBX21 are widely used in immunology research to study Th1/Th2 balance, autoimmune diseases, infections, and cancer. They enable detection of TBX21 protein levels via techniques like Western blotting, flow cytometry, and immunohistochemistry. Such studies have linked TBX21 dysregulation to conditions like multiple sclerosis, rheumatoid arthritis, and asthma. Additionally, TBX21 antibodies help explore its role in tumor microenvironments, where Th1 responses often correlate with improved cancer outcomes.

The development of specific, high-affinity TBX21 antibodies has advanced understanding of transcriptional control in immunity, offering insights into therapeutic strategies targeting immune polarization. These tools remain essential for dissecting pathways governing adaptive and innate immunity.