Nidogen1抗体;Nidogen1 Antibody—艾普蒂 新品

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     Western blot analysis of Nidogen 1 expression in Human fetal heart lysate.    

  
  

Nidogen1. also known as entactin, is a key component of the basement membrane, a specialized extracellular matrix structure critical for tissue organization, cell adhesion, and signaling. It serves as a bridging molecule, facilitating interactions between laminin and collagen IV networks, thereby stabilizing basement membrane architecture. Nidogen1 is expressed in various tissues and plays roles in embryonic development, wound healing, and maintaining tissue integrity. Dysregulation of Nidogen1 has been implicated in diseases such as cancer metastasis, fibrosis, and kidney disorders.

Nidogen1 antibodies are essential tools for studying its expression, localization, and function in biological and pathological contexts. These antibodies are widely used in techniques like immunohistochemistry (IHC), immunofluorescence (IF), and Western blotting to visualize Nidogen1 distribution in tissues or assess its expression levels in experimental models. Researchers employ Nidogen1 antibodies to investigate basement membrane disruptions in genetic knockout studies, tumor microenvironment remodeling, or inflammatory conditions. Additionally, they help validate the success of gene-editing approaches (e.g., CRISPR) targeting Nidogen1. Commercially available antibodies are typically raised in rabbits or mice, with monoclonal and polyclonal variants offering different specificity and sensitivity profiles. Validation via knockout controls or siRNA knockdown is recommended to ensure reliability. Understanding Nidogen1 dynamics through antibody-based assays contributes to insights into tissue repair mechanisms and therapeutic targeting of basement membrane-related pathologies.