BAF57/SMARCE1抗体;BAF57/SMARCE1 Antibody—艾普蒂 新品

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     Western blot analysis of BAF57/SMARCE1 expression in Raji cell lysate.    

  
  

The BAF57/SMARCE1 antibody targets a protein subunit of the SWI/SNF chromatin-remodeling complex, which plays a critical role in regulating gene expression by altering nucleosome structure. Encoded by the *SMARCE1* gene, BAF57 (also known as SMARCE1) is essential for the assembly and stability of the SWI/SNF complex, facilitating its interaction with DNA and transcription factors. This complex is involved in diverse cellular processes, including differentiation, proliferation, and DNA repair. Dysregulation of BAF57/SMARCE1 has been linked to cancers, such as breast and prostate cancer, where it modulates hormone receptor signaling (e.g., estrogen and androgen receptors), and neurological disorders.

Antibodies against BAF57/SMARCE1 are widely used in research to study its expression, localization, and function. They enable techniques like Western blotting, immunohistochemistry, and chromatin immunoprecipitation (ChIP) to assess protein levels, tissue distribution, and DNA-binding activity. Mutations in *SMARCE1* are associated with rare conditions, including Coffin-Siris syndrome and clear cell meningiomas, highlighting its role in development and disease. Researchers also utilize these antibodies to explore SWI/SNF complex integrity in cancer models or genetic screens, providing insights into epigenetic mechanisms and therapeutic targets. Its dual role in transcriptional activation and repression underscores its significance in both normal physiology and pathology.