BTF抗体;BTF Antibody—艾普蒂 新品

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     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

BTF (Bcl-2-associated transcription factor) antibodies are essential tools in molecular and cellular biology for studying the role of BTF proteins in apoptosis, cell cycle regulation, and transcriptional control. BTF, also known as BCLAF1. interacts with Bcl-2 family proteins, which are critical regulators of programmed cell death. It functions as a transcriptional repressor and participates in DNA damage response pathways, linking apoptosis to genomic stability. Dysregulation of BTF expression has been implicated in cancer, autoimmune diseases, and neurodegenerative disorders, highlighting its biomedical relevance.

BTF antibodies are typically generated using immunogenic peptide sequences or recombinant protein fragments, yielding monoclonal or polyclonal variants. These antibodies enable the detection of BTF in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF), allowing researchers to map its expression patterns across tissues and subcellular compartments. Specificity validation via knockout controls or siRNA knockdown is crucial, as BTF shares functional domains with other transcription factors. Recent studies also utilize BTF antibodies in chromatin immunoprecipitation (ChIP) to identify DNA-binding targets, unraveling its role in gene regulatory networks. Commercial availability of validated BTF antibodies has accelerated research into its dual pro- and anti-apoptotic functions, depending on cellular context and post-translational modifications. Ongoing efforts focus on developing phospho-specific antibodies to study BTF's dynamic regulation in stress signaling pathways.