Laminingamma1抗体;Laminingamma1 Antibody—艾普蒂 新品

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     Western blot analysis of Laminin gamma 1 expression in A431 cell lysate.    

  
  

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     All lanes use the Antibody at 1:1k dilution for 1 hour at room temperature.    

  
  

The Laminin gamma1 (LAMC1) antibody targets the gamma-1 chain of laminin, a critical component of the extracellular matrix (ECM). Laminins are heterotrimeric glycoproteins composed of alpha, beta, and gamma chains, with LAMC1 being essential for forming basement membranes (BMs) that support tissue structure and cell adhesion. The gamma-1 chain is ubiquitously expressed and participates in diverse biological processes, including cell differentiation, migration, and tissue development.

Research on LAMC1 antibodies has focused on its role in diseases such as cancer, fibrosis, and genetic disorders. In cancer, elevated LAMC1 expression correlates with tumor progression, metastasis, and poor prognosis, likely due to its involvement in ECM remodeling and angiogenesis. Antibodies against LAMC1 are utilized to study these mechanisms, identify therapeutic targets, or serve as diagnostic markers. For example, they have been applied in immunohistochemistry (IHC) and Western blotting to assess LAMC1 levels in tumor tissues or biofluids.

Additionally, LAMC1 mutations are linked to epidermolysis bullosa and other BM-related disorders, driving interest in antibodies for diagnostic confirmation. Recent studies also explore its role in tissue regeneration and stem cell niches. Despite its significance, challenges remain in developing isoform-specific antibodies due to structural homology among laminin subunits. Overall, LAMC1 antibodies are vital tools for unraveling ECM biology and advancing translational research.