Syntenin抗体;Syntenin Antibody—艾普蒂 新品

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     Western blot analysis of Syntenin expression in HeLa cell lysate.    

  
  

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     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

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     All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    

  
  

Syntenin (also known as SDCBP, syndecan-binding protein) is a multifunctional adaptor protein involved in cellular signaling, adhesion, and membrane trafficking. It contains two PDZ domains that mediate interactions with various binding partners, including syndecans (transmembrane heparan sulfate proteoglycans), ALIX (apoptosis-linked gene 2-interacting protein X), and growth factor receptors. Syntenin plays roles in diverse biological processes such as exosome biogenesis, receptor trafficking, synaptic formation, and cancer metastasis. For example, it facilitates exosomal cargo sorting by bridging syndecan heparan sulfate chains with the ESCRT machinery via ALIX, influencing tumor cell invasion and metastasis. In neurons, syntenin regulates synaptic architecture by interacting with proteins like prosaposin and glutamate receptors.

Syntenin antibodies are essential tools for studying its expression, localization, and molecular interactions. These antibodies are typically developed in hosts like rabbits or mice using immunogenic peptides or recombinant protein fragments. They are validated for applications such as Western blotting (WB), immunofluorescence (IF), and immunohistochemistry (IHC). Specific clones or polyclonal preparations may vary in recognizing distinct epitopes or post-translationally modified forms. Researchers use syntenin antibodies to investigate its roles in cancer progression (e.g., via exosome-mediated communication), neurological disorders (e.g., synaptic dysfunction), and viral entry mechanisms (e.g., HIV-1 attachment). Proper validation, including knockout controls and cross-reactivity checks, is critical due to its homology with other PDZ domain-containing proteins. Commercial antibodies often cite reactivity across human, mouse, and rat samples.