ESRRG抗体;ESRRG Antibody—艾普蒂

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     All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    

  
  

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     Western blot analysis of Estrogen Related Receptor gamma expression in Human fetal heart lysate.    

  
  

The estrogen-related receptor gamma (ESRRG), also known as ERRγ, is a nuclear receptor that regulates gene expression involved in cellular metabolism, energy homeostasis, and mitochondrial function. Unlike classical hormone receptors, ESRRG does not bind endogenous ligands but modulates transcription by interacting with coactivators or corepressors. It plays critical roles in tissues with high metabolic demands, such as the liver, heart, and kidneys, and is implicated in adaptive responses to fasting, exercise, and oxidative stress. Dysregulation of ESRRG has been linked to metabolic disorders, neurodegenerative diseases, and cancers, making it a research target for therapeutic interventions.

ESRRG antibodies are essential tools for detecting and quantifying ESRRG protein expression in experimental models. These antibodies, typically monoclonal or polyclonal, are validated for applications like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and chromatin immunoprecipitation (ChIP). Specificity is confirmed using knockout controls or siRNA-mediated knockdowns. Researchers use ESRRG antibodies to explore its tissue-specific expression patterns, subcellular localization, and interactions with metabolic pathways. For instance, studies highlight its role in promoting mitochondrial biogenesis in muscle or modulating gluconeogenesis in the liver. Reliable ESRRG antibodies are crucial for elucidating its dual roles as a potential oncogene or tumor suppressor, depending on cellular context, and for advancing biomarker discovery in diseases like diabetes or Parkinson's.