Phospho-PKC(S729)抗体;Phospho-PKC(S729) Antibody—艾普蒂 新品

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     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

Phospho-PKC(S729) antibodies are specialized tools used to detect the phosphorylation status of protein kinase C (PKC) at serine residue 729. a critical post-translational modification associated with PKC activation and function. PKC is a family of serine/threonine kinases involved in diverse cellular processes, including proliferation, differentiation, apoptosis, and immune responses. Phosphorylation at specific residues, such as S729 in certain PKC isoforms (e.g., PKCδ), is essential for their full enzymatic activity and stability. This phosphorylation event typically occurs in the catalytic domain and is mediated either by autophosphorylation or upstream kinases, serving as a regulatory mechanism to control PKC signaling.

Antibodies targeting phospho-PKC(S729) are widely used in research to study PKC activation dynamics in response to stimuli like growth factors, hormones, or stressors. They enable the detection of activated PKC in techniques such as Western blotting, immunofluorescence, or immunohistochemistry. These antibodies are particularly valuable in investigating pathological conditions linked to dysregulated PKC signaling, including cancer, neurodegenerative diseases, and cardiovascular disorders. However, specificity validation is crucial, as cross-reactivity with other phosphorylated PKC isoforms or unrelated proteins may occur. Researchers rely on these antibodies to elucidate PKC-related signaling pathways and evaluate therapeutic targets modulating PKC activity.