DIAPH1抗体;DIAPH1 Antibody—艾普蒂

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     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

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     Western blot analysis of DIAPH1 expression in K562 cell lysate.    

  
  

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     All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    

  
  

The DIAPH1 antibody is a research tool targeting the Diaphanous homolog 1 (DIAPH1) protein, a member of the formin family involved in cytoskeletal dynamics. DIAPH1 regulates actin polymerization, microtubule stabilization, and cell motility by interacting with Rho GTPases. It plays critical roles in cellular processes such as cytokinesis, cell migration, and signal transduction. Dysregulation of DIAPH1 has been linked to various pathologies, including cancer metastasis, cardiovascular disorders, and neurodevelopmental conditions like hearing loss (e.g., autosomal dominant deafness-1).

DIAPH1 antibodies are widely used in biomedical research to investigate the protein's expression, localization, and function. They enable detection via techniques like Western blotting, immunofluorescence, and immunohistochemistry. Specific applications include studying DIAPH1's role in tumor invasiveness, endothelial cell permeability, or platelet activation. Some antibodies distinguish between phosphorylated (active) and inactive forms, aiding mechanistic studies. Commercially available DIAPH1 antibodies vary in clonality (monoclonal/polyclonal) and host species, requiring validation using knockout controls or siRNA-treated samples. Recent studies also explore DIAPH1 as a potential therapeutic target, particularly in inflammation and fibrosis, driving demand for reliable antibody reagents. Proper validation remains essential due to occasional cross-reactivity with other formin proteins.